Ligliptin can be taken together with metformin, and the two together can jointly control blood glucose. Ligliptin can control blood glucose by stimulating insulin secretion and also reduce glucagon secretion from pancreatic alpha cells; metformin can reduce blood glucose by inhibiting hepatic glycogen isomerization, increasing glucose uptake and utilization by peripheral tissues, and improving the sensitivity of peripheral tissues to insulin. Ligliptin and metformin lower blood glucose by different pathways and can effectively lower blood glucose. And the combination of drugs does not produce drug interactions. Clinical need to pay attention to the adverse effects of the drug, the use of metformin during the use of lactic acidosis, diarrhea, nausea and vomiting and other adverse reactions, the adverse effects of Rigliptin include hypoglycemia, pancreatitis and so on. Diabetic patients need to follow the doctor’s instructions when using the drug, so as not to lead to adverse consequences.