The main reasons for high total platelet count after chemotherapy for ovarian cancer surgery: hormonal stimulation, adverse reaction to chemotherapy, and infection. If chemotherapy is carried out with hormone treatment, it may lead to platelet elevation. Increase in total platelet count may occur in cases of loss of appetite after chemotherapy, decreased diet with vomiting or infection with pathogenic microorganisms due to decreased immunity of the body. However, most of the platelet elevation in these cases is transient and need not be particularly worried. However, due to the rapid change of the condition of ovarian cancer patients, attention should be paid to monitoring the platelets of the patients, and if persistent elevation occurs, treatment should be carried out immediately so as to avoid adverse reactions aggravating the condition. Nursing care for patients after chemotherapy is also very important. It is suggested that patients should be given fluids or semi-fluids with high calorie and high protein to supplement nutrition in time, and because of the long cycle of chemotherapy treatment, attention should be paid to the psychological care of patients and confidence should be built up. Patients should pay attention to the detection of adverse reactions after chemotherapy treatment, once the situation worsens, immediately seek medical treatment.