Gender disharmony mainly refers to the inability of couples to be satisfied when they have sex. There are many causes of gender disharmony, such as erectile dysfunction, frigidity, and painful intercourse. 1. Erectile dysfunction: it is a common male disease, which means that the penis can’t have a normal erection, or the hardness of erection can’t finish the sexual intercourse, or the time of erection is too short to finish the sexual intercourse, which affects the sexual life and leads to gender disharmony. 2. Sexual frigidity: It can happen to both men and women. Sexual frigidity is mostly due to psychological disorders, excessive pressure, different sexual concepts, hypogonadism, endocrine diseases and other factors. The main clinical manifestation is the lack or lack of sexual interest and desire for sexual activities, which leads to gender disharmony. 3. Pain during sexual intercourse: it can occur in both men and women, but it is more common in women. Painful sexual intercourse is mostly due to psychological factors, gynecological diseases (such as urethritis, vaginitis, etc.), urological diseases (such as penile deformity, phimosis, etc.) and other factors. The main clinical manifestation is sudden or repeated pain during sexual intercourse, thus affecting sexual life and leading to gender disharmony. There are many other causes of gender disharmony, it is recommended that both husband and wife go to the hospital in time to find out the cause of the disease and receive treatment as soon as possible.