Autoimmune liver is autoimmune hepatitis. A positive antinuclear antibody of 1:100 is not necessarily autoimmune hepatitis, but may be the result of other diseases such as systemic lupus erythematosus. In addition, patients with autoimmune hepatitis may also have increased anti-smooth muscle antibodies and elevated alanine aminotransferase, among other findings. Antinuclear antibodies are usually detected by indirect immunofluorescence, and the normal is less than 1:10. If the antinuclear antibody is positive 1:100, it may be caused by autoimmune hepatitis, or by other diseases such as systemic lupus erythematosus, rheumatoid arthritis, desiccation syndrome, scleroderma, mixed connective tissue disease, and drug-induced lupus. Patients with autoimmune hepatitis, in addition to positive antinuclear antibodies 1:100, will also have elevated anti-smooth muscle, anti – actin antibodies, anti-neutrophil plasma antibodies and other test results. In addition to this, patients undergo serum biochemistry tests with elevated alanine aminotransferase, aspartate aminotransferase and other indicators. It is recommended to consult a doctor in case of positive antinuclear antibodies 1:100, who will determine whether autoimmune hepatitis is present, taking into account the patient’s condition and the results of other tests.