Esophageal cancer infiltrating the whole layer without metastasis means that the cancer is currently in the middle stage and the cancer cells have not yet metastasized. Early diagnosis and early treatment of esophageal cancer will have better prognosis. It is recommended that patients actively cooperate with doctors for treatment. Invasive whole layer without metastasis of esophageal cancer means that the cancer cells have infiltrated the whole layer, but no distant metastasis has occurred, which generally belongs to the middle stage of esophageal cancer. Some patients are treated by surgical resection with lymph node dissection, digestive tract reconstruction and other surgical methods. It can improve the surgical resection rate and relieve patients’ uncomfortable symptoms. Early diagnosis and early treatment of esophageal cancer will have better prognosis. Patients in middle and late stages are treated by surgery, drugs, chemotherapy, radiation therapy and other treatments. It can relieve patients’ uncomfortable symptoms, prolong patients’ life cycle and improve their quality of life. It is recommended that patients actively cooperate with doctors for treatment.