As the protective layer of the brain, the skull maintains the normal activity of the brain tissue and allows our body functions to function normally. Cranial defects are very scary, causing localized swelling and pain, as well as different degrees of dizziness, headache, memory loss, poor self-control and other symptoms, and in more serious cases, can also cause atrophy and cystic change of the brain tissue. Based on this danger, cranial defects must be repaired, and it is necessary to choose the right repair material to ensure postoperative recovery. At present, the widely used repair material is titanium alloy, using titanium alloy as the material of repair, there are still many shortcomings and deficiencies. For example, patients are particularly sensitive to hot and cold reactions after the operation, not daring to sunbathe, there is still some slight pain at the edge of the repair, and patients are unable to receive normal medical examination after the operation, and at the same time, the patients cannot be satisfied with the appearance effect. In order to let more patients with cranial defects see the hope of perfect repair, after unremitting efforts, after in-depth exploration, through clinical practice has proved that a new type of material – polyether ether ketone material, also commonly known as PEEK material in the cranial bone as a material for repairing its uniqueness and advancement of its insulation, strength, hardness, elasticity, etc. are the same as the autologous cranial bone, but also the same as the autologous cranial bone. Its heat insulation, strength, hardness, elasticity and so on are comparable with the autologous cranial bone. Through 3D printing technology, the anatomical technology of the cranial bone is perfectly restored, and complex molding is carried out to make it fit perfectly with the edge of the patient’s defects, with excellent cosmetic effect. The application of Peek material is exactly the new trend of cranial bone repair at present.