High blood pressure medication should be based on the patient’s own situation to choose the most appropriate, generally can take the antihypertensive drugs are: diuretics, calcium channel blockers, β-blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists. 1. diuretics: furosemide, thiazides, etc., applicable to simple systolic, mild to moderate hypertension; furosemide can cause electrolyte disorders, need to be vigilant, thiazides are prohibited in high blood glucose, high blood lipids and high uric acid. 2. Calcium channel blockers: Verapamil, nifedipine, etc. are suitable for the elderly with simple systolic hypertension combined with small vessel disease, such as coronary artery disease and peripheral vascular disease. Verapamil will reduce heart rate and is contraindicated in heart failure, pathological sinus node syndrome and atrioventricular block; nifedipine will increase the heart rate and is contraindicated in those with fast heart rate. 3. β-blockers: Metoprolol, etc. are suitable for hypertension combined with fast heart rate, angina pectoris, which can reduce heart rate, and are prohibited for hypertension combined with bradycardia and atrioventricular conduction block. 4. Angiotensin-converting enzyme inhibitors: there are captopril, etc., is the first choice for hypertension with diabetes mellitus, also applies to hypertension combined with myocardial remodeling, urinary protein; renal artery stenosis, pregnancy and irritating dry cough is prohibited. 5. Angiotensin II receptor antagonist: there are chlorosartan and so on. Indications and contraindications are the same as angiotensin-converting enzyme inhibitors, but when combined with irritating dry cough, angiotensin II receptor antagonists are required. Clinical hypertension mechanism is complex, a variety of drugs, need to consult a doctor in time, according to the doctor’s recommendations for individualized use of drugs.