B27 positivity will generally be lifelong. B27 is human leukocyte antigen 27, and generally B27 positivity cannot be reversed; this positivity is genetically linked and will be lifelong. HLA-B27 positivity means that the HLA-B27 gene is expressed on the nucleated cells of the person’s patient being tested. HLA-B27 is associated with ankylosing spondylitis, with approximately 90% of people with ankylosing spondylitis being HLA-B27 positive, and normal people with HLA-B27 positivity are more likely to develop ankylosing spondylitis than those who are negative. There may be genetic differences between HLA-B27-positive healthy people and ankylosing spondylitis patients, so a positive HLA-B27 gene means that the patient has inherited the HLA-B27 gene, and therefore cannot confirm the diagnosis of ankylosing spondylitis. It is recommended to go to the hospital in time, further improve the blood routine, imaging tests and other related tests, and follow the doctor’s instructions for treatment.