A gallbladder wall thickness of 5mm gross is usually not very serious, depending on the cause of the wall thickening. In most cases, the occurrence of thickening of the gallbladder wall is not very serious. It may be caused by the usual bad habits or irregular diet, etc. It is mostly seen in chronic cholecystitis and gallbladder stones. In addition, adenomyosis of the gallbladder can also cause thickening of the gallbladder wall, which only requires surgery to remove the gallbladder and is not considered a serious disease. However, if the thickening of the gallbladder is caused by gallbladder cancer, it is very serious and rare in the clinic. Timely surgery, radiotherapy, chemotherapy and other treatment options are needed. If the gallbladder wall is 5mm thick, it is best to go to the hospital regularly to observe whether there are any changes, so that timely treatment can be taken.