The indications for chemotherapy for pancreatic cancer include postoperative adjuvant chemotherapy, preoperative neoadjuvant chemotherapy, and palliative subtractive chemotherapy in advanced stage, and the contraindications include advanced malaise, poor physical score, the presence of severe infections or hemorrhagic symptoms, and severe reduction of white blood cells, hemoglobin, or platelets. The indications of chemotherapy for patients with pancreatic cancer include the following. 1. patients with high risk factors for recurrence and metastasis after radical surgery or radiotherapy. 2. Some cardia cancer patients with large tumors have difficulties in radical surgery, so they can undergo preoperative chemotherapy to shrink the tumors so that they can be radically resected. 3. Patients with advanced extensive metastasis and good physical strength score can take palliative chemotherapy to fight against tumor. The more common contraindications to chemotherapy for cardia cancer include the following. 1. advanced patients with malignant fluid status or poor physical strength score. 2. Patients with cardia cancer with severe infection or gastrointestinal bleeding and other complications. 3. Patients are in the state of bone marrow suppression, for example, white blood cell is lower than 3.0×10~9, or platelet is lower than 75×10~9, or severe anemia, hemoglobin is lower than 60g/L, etc.