Dry cough without sputum at night cough is more commonly caused by respiratory diseases such as colds, mycoplasma pneumonia, lung cancer, tuberculosis, etc., digestive diseases such as gastroesophageal reflux disease, such people should consult a doctor in a timely manner, to determine the cause of the disease and then treatment. 1. Respiratory diseases that can cause dry cough without sputum include cold and flu, mycoplasma pneumonia, lung cancer and tuberculosis. (1) Colds: Viral or bacterial infections of the upper respiratory tract, patients will have a dry cough that is heavier at night, sneezing, nasal congestion and so on. (2) Mycoplasma pneumonia: respiratory tract infection caused by Mycoplasma pneumoniae, patients will have symptoms such as dry cough, fatigue, headache and swollen lymph nodes. (3) Lung cancer: malignant tumors originating from the bronchial mucosa or glands in the lungs, patients will have symptoms such as dry cough, hemoptysis, dyspnea and fever which are more serious at night. (4) Tuberculosis: respiratory infectious disease caused by Mycobacterium tuberculosis infecting lung tissues, trachea and bronchial tubes, patients will have symptoms such as dry cough, hemoptysis, low fever in the afternoon and night sweating, etc., which are more serious at night, and can be treated with medicines such as isoniazid, rifampicin, pyrazinamide, etc., under the guidance of doctors. 2. Digestive system diseases: the digestive system diseases that can cause the dry cough to worsen at night are gastroesophageal reflux disease (GERD), i.e., the discomfort caused by the reflux of stomach contents into the esophagus, and patients will have heartburn, severe dry cough at night, and a feeling of a foreign body in the throat, etc., which can be treated with medicines such as omeprazole and famotidine. Dry cough without phlegm cough at night there are many other reasons, such as cough variant asthma, cardiac insufficiency, etc. It is recommended that the patient actively go to the hospital, a clear diagnosis, in the doctor’s instructions under the use of medication, do not take their own medication, so as not to delay the condition.