Retinoblastoma has no metastatic pathology after removal of the eye, most patients have a low chance of recurrence, and regular follow-up as prescribed by the doctor is sufficient. Retinoblastoma is a kind of malignant lesion originated from the precursor cells of photoreceptors in the eye, which often occurs in infants and young children. Once retinoblastoma is detected, surgical treatment such as eyeball removal should be performed as soon as possible. If the treatment is timely and there is no intracranial or distant metastasis, the majority of patients have a low chance of recurrence after eye removal, and regular checkups are sufficient. Even if there are no risk factors for retinoblastoma after eye removal surgery, patients need to go to the hospital for regular checkups as instructed by the doctor, mainly cranial MRI, which can help to know the health status of the patients in a timely manner. It is recommended that patients who have no metastasis after surgery generally have optimistic conditions, but they must follow up and review according to the doctor’s instructions to avoid delaying their condition.