A high level of creatine kinase isoenzyme indicates that a person’s heart muscle has been damaged to a more severe and extensive degree. Disease and non-disease factors are the main causes of high creatine kinase isoenzyme, as follows: 1. Disease factors are myocarditis, pericarditis, myocardial infarction, chronic atrial fibrillation, myasthenia gravis, progressive muscular dystrophy, myasthenia gravis, polymyositis, surgery, trauma, cerebral infarction, acute craniocerebral injuries, convulsions and epileptic seizures, cerebral hemorrhage, meningitis, and malignant tumors. 2. Non-disease factors are mainly cardiac surgery, exercise, installation of pacemakers, radiofrequency ablation therapy and so on. Certain medications can cause damage to the gluteal muscles, leading to elevated creatine kinase isoenzymes. As each patient’s condition is different, it is recommended to go to the hospital for detailed examination and treatment under the guidance of physicians.