A total bilirubin of 41 μmol/L is in the abnormal range and is usually severe. The normal range for total bilirubin is 0-17.1 μmol/L, above which it is considered high. If the total bilirubin result is 41 μmol/L, it has exceeded the normal range twice, which is usually more serious. Total bilirubin can be divided into direct bilirubin and indirect bilirubin. Elevated direct bilirubin is mostly seen in gallstones, obstructive jaundice, pancreatic head cancer, hepatocellular carcinoma, etc. Elevated indirect bilirubin is mostly seen in chronic active hepatitis, acute hepatic necrosis, cirrhosis and hemolytic anemia, etc. Liver function, liver, gallbladder and spleen ultrasound, CT and other investigations should be conducted to clarify the cause of the disease. If the test result of total bilirubin is abnormal, it is recommended to consult a doctor in time and carry out targeted treatment or therapy under the doctor’s guidance to minimize the adverse effects of the disease.