Soreness and tiredness on both sides of the cheeks can be considered related to bad habits, temporomandibular joint disorder syndrome, mumps and other causes. 1. Bad habits: for example, when chewing hard food, muscle contraction can be strengthened to enhance the bite force, resulting in soreness and tiredness of the cheeks. Or when you have the habit of grinding or clenching your teeth at night, it can enhance the biting force, leading to soreness and tiredness of the cheeks. 2. Temporomandibular joint disorder syndrome: when the muscles around the joints are over-excited or over-inhibited, the occlusal relationship of the teeth is disturbed, and the joints are congenitally malformed, it can lead to temporomandibular joint disorder syndrome. It is manifested as masticatory muscle dysfunction, soreness and pain of biting muscle, temporal muscle and external pterygoid muscle, which leads to soreness and tiredness of the cheeks. 3. Parotitis: When the parotid gland is infected, it causes swelling and pain in the parotid area. When the parotid gland is swollen for a long period of time, the parotid gland will become sore and tired. When the parotid gland is swollen for a long time, the parotid gland will become sore and tired. When the soreness and tiredness of the parotid gland persist, it is recommended to go to the hospital in time in order to clarify the cause of the soreness and to facilitate the treatment.