Itchy and flaky palms can be a symptom of tinea cruris, eczema, exfoliative keratolysis or herpes perspiration. Need to go to the dermatology department under the guidance of the doctor treatment and medication. 1. Ringworm is caused by a fungal infection, transmitted through skin-to-skin contact, and can be transmitted to each other through handshakes and other actions, as well as to the hands by the fungus on their own body parts. Ringworm usually starts unilaterally, there are many small blisters under the skin of the palm of the hand, the blisters dry up and burst, itching is obvious, and it can spread to the palm of the opposite side. 2. Eczema is the body is stimulated by internal and external factors after the emergence of perverse reactions, manifested as bilateral palms symmetrical blisters, peeling skin, itching obvious. 3. Exfoliative Keratolysis is related to heredity and vitamin A deficiency, manifesting as a symmetrical appearance of large areas of blistered skin on the palms of both hands, accompanied by mild itching or pain. 4. Sweat herpes is a special type of eczema, many of which are caused by wearing watches, rings and other metal jewelry on the hands. The manifestation is the appearance of symmetrical deep blisters under the skin of both hands, the blisters itch significantly, the blisters dry up to form scattered flakes. There may be other causes of itchy skin bursting on the palms of the hands, it is recommended to go to the hospital in a timely manner, a clear diagnosis, symptomatic treatment.