Nursing care of patients with multiple organ failure, multiple organ failure patients are often some of the patients with acute and critical illnesses, so this type of patient care strategy often includes two parts: one is called basic care, basic care includes some of the patient’s mouth and turn over, because often the patient’s reaction is not good or to use large doses of analgesic sedative drugs, need to give him daily bath, turn over, back patting, and elevate the head of the bed to prevent the occurrence of pressure ulcers after lying in bed related care. The first is the care of the patient’s mouth and turnover, because often the patient does not respond well or has to use a high dose of analgesic and sedative drugs, and needs to be given daily baths, turnover, back patting, and some care to elevate the head of the bed to prevent pneumonia, as well as some care related to the development of pressure ulcers after lying down. The second is to target the occurrence of organ failure organs to care, such as respiratory failure patients, respiratory failure patients may also be oxygen, according to the patient’s hypoxic state to develop a reasonable oxygen therapy program, may use a nasal cannula to give oxygen or mask to give oxygen, if not able to correct the transition to mechanical ventilation, also known as tracheal intubation to give him assisted respiration, and then this requires a ventilator related care. Do a ventilator-related care, such as respiratory function monitoring, and then timely to the airway for sputum suction, or a daily mechanical sputum care; and then if there is renal failure of the patient, the nursing staff may need to pay attention to the patient’s urine output, lower limb edema, if it is indeed the state of urinary output of urinary urine or anuric state, there is an acute renal injury, may be renal replacement therapy, also known as CRRT, which is the first time in the world that the patient has been in the hospital. If the patient is indeed urinating or anuric, and has acute kidney injury, renal replacement therapy, also known as CRRT, may be performed, which requires the nurse to operate the equipment and maintain the blood line under the guidance of the doctor’s formula. Patients with circulatory failure should be monitored for heart rate, blood pressure, oxygen, and conscious state, and the dosage of vasoactive medications should be adjusted in a timely manner, primarily based on strategies to target care to the compromised system.