The “magic cure for colitis” is false. There is no “magic cure for colitis”, this claim lacks scientific basis. The goal of colitis treatment is to maintain a state of remission and promote mucosal healing, prevent and treat complications, and improve the patient’s quality of life. Generally, drug therapy is adopted, and antibiotics, aminosalicylic acid preparations, glucocorticoids, immunosuppressants, biological agents are commonly used, as follows. 1. Antibiotics: acute colitis is mostly related to intestinal bacterial infection. Overgrowth of intestinal bacteria can damage the intestinal mucosa and produce inflammation. Antibiotic treatment can alleviate the symptoms of some patients, commonly used are metronidazole or ciprofloxacin. 2. Aminosalicylic acid preparation: it is the main drug for the treatment of inflammatory bowel disease, commonly used 5-aminosalicylic acid (mesalazine, olanzapine) and salazosulfapyridine. 3. Glucocorticoids: used in the acute active phase of inflammatory bowel disease, the treatment of moderate and severe patients; commonly used oral prednisone, intravenous hydrocortisone and methylprednisolone. 4. Immunosuppressant: used for 5-aminosalicylic acid treatment of inflammatory bowel disease with poor efficacy, recurrent symptoms and hormone dependence of the maintenance therapy, commonly used preparations are azathioprine and mercaptopurine. 5. Biological agents: used for inflammatory bowel disease by hormone and immunosuppressant treatment is ineffective or intolerable, such as infliximab monoclonal antibody. Diagnosed with colitis should follow the doctor’s instructions to actively treat, do not blindly believe that the “prescription”.