Rheumatoid arthritis can cause knee pain, and the common areas of involvement are the wrist, palm and fingers, followed by the toes and ankles, which are most often accompanied by symptoms such as joint swelling, pain, limitation of movement, fever, and fatigue. Rheumatoid arthritis is an autoimmune disease, mainly characterized by joint lesions. Usually, rheumatoid arthritis commonly affected parts are wrists, palms, fingers, but some patients may also have knee joint pain, and there will be pressure pain, also accompanied by swelling, morning stiffness, mobility disorders, joint deformity and other manifestations. Besides, the affected parts of rheumatoid arthritis include toes, ankles, shoulder joints and elbow joints. Secondly, a small number of patients may also experience systemic symptoms such as fever, fatigue, loss of appetite and weight loss. There is no cure for this disease, and the related treatments can only alleviate the symptoms and control the condition, and the prognosis is generally good. When patients experience the above symptoms, rheumatoid arthritis should be suspected, and they should go to the rheumatology department of the hospital in a timely manner to get a clear diagnosis and timely treatment.