Diseases caused by coxsackievirus include herpes pharyngitis, rash disease, meningitis, encephalitis, myelitis, pericarditis, myocarditis, or systemic infections, or upper respiratory tract infections in pediatric patients. Coxsackievirus is an enterovirus that is divided into two categories, A and B. Its transmission is mainly through fecal-oral transmission or oral-oral transmission, so Coxsackievirus is highly contagious, especially in kindergartens and nurseries. If patients are found to be infected with Coxsackie virus, they must be isolated and treated in a timely manner. It is also emphasized that tableware should be thoroughly disinfected and the environment of kindergartens and nurseries should be disinfected on a regular basis. Patients should wear masks, wash their hands frequently, ensure normal safe distances, and thoroughly disinfect toys as well, and take a break from school as well as complete isolation after illness. Because it is more transmissible, but the treatment is more effective, the main treatment is symptomatic treatment as well as rest to control the effects caused by the disease on the organism.