There is no best medicine for tongue cancer, so patients are advised to follow the doctor’s instruction to use medicine, surgery and so on. Tongue cancer is a kind of malignant tumor, and most of them are squamous cell carcinoma. Patients should pay attention to the fact that there is no best medicine for tongue cancer, and should avoid choosing the biased prescriptions or “special drugs” without scientific basis, in order to prevent aggravating the condition and affecting the recovery of body health. Clinically, tongue cancer patients can have their lesions removed by surgery, so as to minimize the removal of normal tissues and preserve the function of tongue. Besides surgical treatment, tongue cancer patients can also be treated with radiotherapy, targeted therapy, PD-1 immunotherapy and chemotherapeutic drugs such as cisplatin, fluorouracil and paclitaxel. It is suggested that tongue cancer patients should adjust their mentality and actively cooperate with doctors in order to control the progress of the disease and improve the survival rate. If tongue cancer makes patients unable to eat orally, enteral nutrition or parenteral nutrition is feasible when necessary. Please strictly follow the doctor’s prescription and do not use drugs by yourself.