At the age of 48, 4 months without menstruation, may be endocrine disorders, but also may be the menopause, need to be assisted by other tests to determine. If the patient is 48 years old and has not had a period for 4 months, the first thing to do is to complete the relevant examinations to rule out hyperprolactinemia, hyperthyroidism and other causes of menstrual irregularities. If the ultrasound suggests that the endometrium is abnormally thickened, then the irregular menstruation may be caused by other diseases and there is no menopause. However, if the ultrasound indicates that the endometrium is very thin, and the hormone levels of follicle stimulating hormone and luteinizing hormone in the hormone profile of a woman are greater than 40 u/l, and there is no other disease, then the lack of menstruation at the age of 48 years and 4 months may indicate menopause. It is recommended that patients who are 48 years old and have not had menstruation for 4 months should seek timely and complete the relevant examinations, so as to avoid delaying the treatment of menstrual irregularities caused by other diseases.