The causes of waking up at night with a headache may be migraine, tension headache, cerebrovascular disease. 1. Migraine headache, mostly on one side of the headache, can also be manifested as bilateral headache, symptoms of episodic and throbbing headache, if often have this state, consider the possibility of migraine. 2. Tension headache, generally is the whole head of the tight band of pain, if the sleep is not good, consider the possibility of tension headache. 3. Cerebrovascular disease, if the nature of the pain is very intense, and accompanied by nausea, vomiting, etc., need to pay attention to the cerebrovascular, such as cerebral hemorrhage, subarachnoid hemorrhage and so on. Wake up at night headache, may be primary, may be secondary, it is recommended to go to the Department of Neurology, to find the cause of the disease and give targeted treatment.