The criteria for confirming the diagnosis of new coronavirus have been updated and improved, with the addition of new coronavirus-specific antibody test as a diagnostic reference, but a positive nucleic acid test for new coronavirus is still the gold standard for confirming the diagnosis. According to the “Novel Coronavirus Pneumonia Diagnosis and Treatment Program (Trial Ninth Edition)” issued by the National Health Commission, which is the latest version of the Novel Coronavirus Pneumonia Diagnosis and Treatment Program, the principle of confirming the diagnosis of the Novel Coronavirus is based on comprehensive analysis of epidemiological history, clinical manifestations, and laboratory tests. Positive nucleic acid test for novel coronavirus remains the primary criterion for confirmation of diagnosis. For those who have not received the new coronavirus vaccine, the new coronavirus-specific antibody test can be used as a reference for diagnosis. For those who have received the novel coronavirus vaccine and those who have been previously infected with the novel coronavirus, in principle, antibodies are not used as a basis for diagnosis. If you suspect that you are infected with the new coronavirus, you can consult your community or a designated medical institution in time and improve the new coronavirus nucleic acid test under the guidance of a physician. Note: The terms “new coronavirus pneumonia” and “new coronavirus pneumonia” mentioned in this article were renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.