A trilineage decrease indicates a decrease in red blood cells, white blood cells, and platelets. The trilogy refers to the erythroid, granulocyte, and megakaryocyte lineages, and trilogy reduction is usually seen in other disorders such as decreased hematopoiesis of the bone marrow, increased destruction of blood cells, and severe infections. 1. Decreased hematopoietic capacity of bone marrow can be seen in aplastic anemia, leukemia, myelofibrosis and so on. 2. Increased hematopoiesis can be seen in myelodysplastic syndromes, cirrhotic portal hypertension, paroxysmal sleep hemoglobinuria, and autoantibody-mediated hematopoiesis. 3. Tertiary hypoplasia can also be seen in other conditions such as severe infections. There are many other causes of trisomy 21 hypoplasia, and it is recommended to visit a specialist and have a bone marrow examination if necessary. Diagnosis and treatment are under the supervision of a physician.