Low α-hydroxybutyrate dehydrogenase is usually caused by genetic factors, drug factors and other reasons. 1. Genetic factors: the normal value of α-hydroxybutyrate dehydrogenase in human serum is generally between 90u and 220u, some patients have congenital low hydroxybutyrate dehydrogenase, which is due to the lack of lactate dehydrogenase H isoforms caused by the genetic variations, which is congenital. Patients can take polysaccharide iron complex capsule, donkey gum blood replenishing granules, Agaricus gum blood replenishing oral solution and other drugs under the guidance of the doctor to carry out treatment, which can increase the body’s nutrition and improve the symptoms. 2. Drug factors: If patients have recently taken immune agents, anti-cancer drugs, such as dexamethasone tablets, cyclosporine soft capsule, Tong Guan Vine tablets, etc., or have undergone chemotherapy, it will lead to low alpha-hydroxybutyric acid dehydrogenase, which is a normal phenomenon, and does not require special treatment. It is recommended to consult a doctor in time for relevant examination, according to the specific situation, under the guidance of the doctor for symptomatic treatment.