Prostate puncture examination can also be done over 80 years old. The contraindications for prostate puncture test are patients with fever, patients with hypertension crisis, patients with heart disease with cardiac failure, patients with severe bleeding tendency disease, diabetic patients with unstable blood sugar, etc. There is no contraindication in age, if there is no complication as mentioned above, it is possible to do it just purely at the age of 80 years old. Prostate puncture examination can obtain prostate tissue, as an important means of confirming the diagnosis of prostate cancer, the puncture route has two kinds of transperineal and transrectal. Prostate puncture examination is suitable for rectal palpation to touch the hard nodule, suspected of tumor; ultrasound found prostate hypoechoic nodule or MRI found abnormal signal, suspected of tumor; serum prostate-specific antigen>10.0ng/ml and other cases. It is recommended that patients should undergo prostate puncture examination under the guidance of the doctor.