Colds are usually caused by viral infections, and the presence of very yellow, pus-filled sputum and pus-filled nasal discharge is mostly due to secondary bacterial infections. Treatment includes symptomatic therapy and anti-infection therapy. 1. Symptomatic treatment: Nasal congestion can be treated with hydroxymetazoline hydrochloride nasal drops to facilitate nasal ventilation, which is prohibited for pregnant women, children and atrophic rhinitis; pus phlegm can be treated with phlegmolytic drugs such as aminoglutethimide tablets, which can reduce the consistency of sputum and accelerate the discharge of pus and phlegm, and is recommended for use by pregnant women and breastfeeding mothers. 2. Anti-infective treatment: colds will appear very yellow pus sputum and pus nasal discharge is considered secondary to bacterial infection, clear need to give antibiotic anti-infective treatment, such as macrolides azithromycin, etc., allergic to this type of drug is prohibited. If the above symptoms occur, it is recommended to consult a doctor in time, complete the relevant examinations to clarify the cause of the disease and carry out targeted treatment. The above medications should be used under the guidance of a doctor, avoid self-medication.