During the period of taking entecavir, the patient’s condition is stabilized when the new crown vaccine can be given, if the patient is in the acute exacerbation period, the condition of the patient is still unstable during the period of the new crown vaccine needs to be postponed. If the vaccinee is taking entecavir, it is usually during the treatment of hepatitis B. When the disease is relatively stable, the new crown vaccine can be administered under the guidance of the doctor, and the main effect of the new crown vaccine is in the immune system, which usually does not have a significant impact on liver disease. However, if the vaccinee’s condition is still unstable, liver function is obviously abnormal, such as serum aminotransferase more than five times the normal value, it is not excluded that the liver disease has entered into an acute exacerbation, and it may belong to the clear contraindication of the new crown vaccine, and at this time, you need to consult with your own primary care doctor in time, and then proceed with the vaccination after obtaining the consent of the doctor.