Foot rubbing out blisters can be treated by general treatment, puncture treatment, medication and other measures. The blisters are considered to be caused by excessive local friction stimulation, resulting in increased exudate from the subcutaneous tissue. 1. General treatment: if the blisters are small, generally pay attention to rest, wear loose shoes, cold compresses within 48 hours, hot compresses after 48 hours, most of the blisters will be absorbed on their own, without special treatment. 2. Puncture treatment: If the blisters are large and the exudate is more, you should use iodophor to routinely sterilize the blisters, and use a sterile needle to puncture the bottom of the blisters to discharge the exudate, and then use sterile gauze or band-aid bandage. 3. medication: if there is a secondary bacterial infection and other complications, you can use erythromycin ointment, mupirocin ointment and other antibiotic drugs. Feet wear out blisters, need to consult a doctor in time, all drugs should be used under the guidance of a professional doctor.