Invasion of middle hepatic vein and neighboring inferior vena cava may mean that liver cancer has appeared and has invaded middle hepatic vein and inferior vena cava, which should be examined to make a clear judgment and be treated actively under doctor’s guidance. The appearance of liver cancer may easily invade the venous blood vessels. Through CT enhancement scanning, it may be found that the important blood vessels have been invaded, which may not have any symptom, and with the seriousness of the disease, it may have symptoms such as pain, emaciation and fatigue, etc. It is necessary to carry out treatments under the guidance of doctors in order to improve the survival period of the patients. Invasion of middle hepatic vein and neighboring inferior vena cava indicates that liver cancer has progressed to a more advanced stage and the condition is more serious, which needs timely treatment. It is recommended to go to regular hospital for standardized treatment in time to avoid delaying the condition.