Oral vestibular groove pain is usually caused by periapical inflammation, treatment includes anti-inflammatory pain relief, incision and drainage of pus, removal of irritation, etc., as follows. 1. Anti-inflammatory pain relief: oral antibiotic drugs or pain medication for pain relief, such as ibuprofen, metronidazole, etc., for periapical inflammation has a certain effect on pain relief, the drug should be used under the guidance of a doctor. 2. Incision and drainage of pus: for severe pain of apical periapical inflammation incision and drainage of pus in order to effectively relieve pain, under local anesthesia to incise the abscess, placed drainage strips, until no pus outflow. 3. Remove irritation: For periapical inflammation caused by chemical irritation, the irritant should be removed, the root canal should be flushed and resealed. In periapical inflammation due to root canal overfilling, the root filling should be removed and the canal should be sealed and pacified. There may be other causes of pain in the vestibular groove of the mouth, and it is advisable to visit the hospital promptly.