Cholestrol soft capsule and amoxicillin can be taken together. Cholestrol soft capsule belongs to the Chinese patent medicine, the main ingredient is menthol oil, can be used for cholecystitis, gallstones treatment; Amoxicillin belongs to the penicillin class of antimicrobial drugs, through the inhibition of the synthesis of the bacterial cell wall to play an antibacterial effect. The two have different mechanisms of action, and the adverse reactions will not be superimposed, so they can be taken together. The adverse reactions and contraindications of bile soft capsule are not clear. Amoxicillin can lead to allergic reactions after use, and in severe cases can lead to anaphylactic shock, so skin tests are required before use, and positive reactions are prohibited. Long-term, high-dose use of the drug can lead to dysbiosis, the emergence of dual infection caused by Candida or drug-resistant bacteria. Note that it is contraindicated in patients who are allergic to penicillin or have a history of the disease. Patients should use the drug under the guidance of professional physicians, do not use the drug without authorization.