Repeated lifting and lowering of body weight needs to be considered for the following reasons, such as physiological factors, irregular life and diet, kidney diseases, and medication factors. 1. Physiological factors: Generally, people have a dynamic process of weight change during the day, which is related to eating, defecation and so on. 2. Irregular life and diet: Sudden overeating, intake of high-calorie food and lack of proper exercise will easily lead to weight gain, but after resuming normal diet and cooperating with exercise, weight loss will generally occur. Repeated irregularities in life and diet will not only make weight rise and fall repeatedly, but also unfavorable to gastrointestinal function. 3. Kidney disease: Chronic kidney disease, such as proteinuria, hypertension, edema as the main clinical manifestations of chronic nephritis, edema symptoms will lead to weight gain, but with proper treatment and care, edema subsides and weight loss occurs, and so on and so forth, the weight will rise and fall repeatedly. 4. Drug factors: taking hormone drugs, such as glucocorticoids will cause “full moon face, buffalo back” symptoms, at the same time will lead to weight gain, generally under the guidance of the doctor to stop using the drug, the weight will drop. If the weight rises and falls repeatedly and is accompanied by other discomforts, please consult a doctor in time for treatment of the primary disease.