Neonatal cerebral palsy may be associated with preterm labor, intrauterine hypoxia, asphyxia, etc. It can be treated with rehabilitation and medication. Newborns with cerebral palsy without handgrip may also be accompanied by increased muscle tone, poor mental health, and dull eyesight, which require prompt medical attention and active treatment through rehabilitation and medication. Comprehensive rehabilitation treatment generally refers to the later crawling training, balance training, motor training, and improve the ability of the newborn to control himself/herself. Hand muscle training can be performed regularly. Drug therapy is mainly to use some nutritional nerve drugs, repair brain tissue, enhance brain function. It can also be combined with the use of related equipment to carry out specific exercises to improve the above situation. Cerebral palsy in newborn babies with hands not making a fist is recommended to seek medical treatment in time to avoid delaying the condition.