The ulceration of the corners of the mouth can be seen in infectious, traumatic, contact and malnutrition keratitis, which needs to be treated by removing the irritating factors and taking medications for the cause. 1. Infectious keratitis. Microbial infections such as fungal, bacterial or viral infections of the oral cavity cause keratitis using different medications, such as fluconazole for fungal infections, chlorhexidine solution for bacterial infections and acyclovir ointment for viral infections. 2. Traumatic keratitis. When trauma can appear traumatic keratitis, the treatment mainly use hydrogen peroxide and other anti-inflammatory solution local rinse or wet compresses, local application of povidone iodine. 3. Contact keratitis. When contact with allergic substances can be triggered by localized erosion and cracking of the corners of the mouth, generally remove the allergens and use anti-allergy drugs loratadine treatment. 4. Malnutrition keratitis. Malnutrition, vitamin deficiency or immune function abnormalities can also cause inflammation of the corners of the mouth, local treatment using chlorhexidine wet compresses or coated with antibiotic ointment, systemic treatment of supplemental vitamin B2, folic acid, and so on. If you want to get rid of the ulcers in the corners of your mouth quickly, you need to go to the hospital first to check the cause of the disease and treat the cause. The use of drugs need to follow the doctor’s instructions.