There is no fastest way to eliminate the ulcers at the corners of the mouth in children, and suitable treatments need to be chosen according to different causes, which can be seen in physiological factors, and may also be caused by infectious diseases, trauma, and so on. Common treatments include general treatment and medication. 1. For children, the habit of pursing, picking or biting the mouth when the mouth is dry may cause ulceration at the corners of the mouth, which needs to change the bad habits, drink more water, disinfect the local area with iodophor, apply lip balm, and so on. 2. Infectious diseases: If there is herpes simplex virus infection, skin ulceration can occur, need to use antiviral drugs, such as oral acyclovir, vasiclovir, etc., local application of acyclovir ointment. Some children have fungal infections, clean up and apply topical tretinoin econazole cream, ketoconazole ointment and so on. 3. trauma: trauma caused by the corners of the mouth ulcers, can need to be sterilized with iodine povidone and then apply erythromycin ointment, fusidic acid cream and other treatments. Therefore, it is recommended that the corners of the mouth ulcers timely consultation, identify the cause of the disease, targeted treatment.