The occurrence of intestinal obstruction after total gastrectomy is associated with mechanical factors, and to a lesser extent with neurogenic mechanisms and inflammatory neuronal interaction mechanisms. 1. Intestinal obstruction after total gastrectomy can be caused by mechanical factors, such as intestinal torsion, intestinal paralysis, internal hernia, intussusception, anastomotic stenosis and other intestinal obstruction. 2. The nerve phase of postoperative intestinal obstruction, surgery, stress, postoperative pain and other signals, will lead to sympathetic, parasympathetic, intestinal intrinsic nervous system reflex regulation, and ultimately can be through the patient’s body gastrointestinal hormones and a variety of intestinal neurotransmitters of the joint action, leading to postoperative gastrointestinal dyskinesia. 3. Postoperative intestinal obstruction inflammatory phase, the role of inflammatory mediators is one of the key reasons for the occurrence of postoperative intestinal obstruction. Inflammatory reaction occurs within the intestinal wall of the patient, and the release of secreted pro-inflammatory factors are all increased, leading to impaired barrier function of the intestinal mucosa, migration of bacteria and their products, and the production of an inflammatory cascade reaction, leading to extensive adhesion of inflammatory lesions in the abdominal cavity. After gastrectomy intestinal obstruction, patients need to actively consult the doctor, cooperate with the doctor to follow the doctor’s instructions reasonable treatment, to avoid aggravation of the condition.