Headaches after staying up all night can be treated through physical therapy, medication and general treatment. 1. Physical therapy: when a slight headache occurs after staying up late, patients can take appropriate massage and apply hot towels to help relax the muscles, relieve mental tension, and help improve the symptoms of headache after staying up late. 2. medication: when the symptoms of headache after staying up late are more obvious, it is recommended that patients take ibuprofen and acetaminophen and other painkillers under the guidance of a doctor. 3. General treatment: patients with headaches after staying up late should also develop good habits, try to avoid staying up late for a long time, and ensure sufficient sleep time. Headache after staying up all night may also be neurological headache or tumor compression and other causes, the patient should go to the hospital, clear reasons to choose the appropriate method of treatment.