There is no clinical basis to confirm whether or not benzbromarone has an effect on creatinine, but benzbromarone may affect kidney function in patients. Benzbromarone is a white to slightly yellow crystalline powder that is a potent promoter of uric acid excretion. Clinically, it is mainly used for primary and secondary hyperuricemia, gout, gouty arthritis and other diseases. Patients may experience gastrointestinal discomfort, nausea, vomiting, gastric fullness and diarrhea when using benzbromarone. Clinically, benzbromarone is prohibited for those who are allergic to benzbromarone, pregnant women, lactating mothers, those with moderate to severe renal impairment and those suffering from kidney stones. Clinically, patients taking Benzbromarone for a long period of time need to pay attention to regular checks of liver and kidney functions, and if persistent diarrhea occurs, the drug should be stopped immediately. It is recommended that patients go to a regular hospital in a timely manner to identify the cause, the specific use of medication in accordance with the guidance of the doctor’s visit.