Epidermolytic hyperkeratosis ichthyosis (epidermolytichyperkeratosisichthyosis), also known as herpetic ichthyosis-like erythroderma, is an autosomal dominant disorder. Armor-like scales that appear at birth or shortly after birth may cover most or all of the body, and are shed to reveal a congested moist surface where new scales soon appear. The key points in the diagnosis of hyperkeratosis are: 1. Present at birth. 2, the lesions are heavier in the flexion side, especially in the armpit, inguinal area, wrist and elbow and other folds are more obvious, and even appear gray-brown warty scales. 3. The whole body is covered with armor-like scales, and after the scales fall off, there is rough and moist epidermis, which can be seen as flaccid blisters, on which scales appear again, and so on and so forth. 4, the lesions can be all over the body, can also be limited and linear and other heterogeneous, such as porcupine ichthyosis that is to warty proliferation and scales of a heterogeneous type. 5.Chronic course, but the condition with the growth of age has a tendency to gradually reduce. 6.Histopathology shows that the epidermis is obviously hyperkeratotic, and there may be papillomatous hyperplasia, intracellular edema in the granular layer, resulting in the loosening of the keratinocytes and degeneration of the granules.