Black blood blisters on the tongue are not usually AIDS. When black blood blisters appear on the tongue, the tongue trauma where the blisters appear should be addressed before making a diagnosis. AIDS patients may have a variety of infections due to severely impaired immune function. White or gray-brown tongue moss and large, deep ulcers in the mouth may appear on the tongue, and black blood blisters do not usually appear, i.e., the appearance of black blood blisters on the tongue is generally not directly related to AIDS. In general, black blood blisters on the tongue are most often seen as a result of tongue trauma caused by cuts to the tongue mucosa by teeth or hard objects. Cancer of the tongue may appear as a white spot or cauliflower-like change with unclear borders that are usually rough to the touch, and it is likely that black blood blisters will also appear at a later stage. If a black blood blister is found on the tongue, firstly, there is no need to be overly concerned, and secondly, to avoid infection, do not pick it yourself with a sharp object. It is recommended that the patient go to the hospital to determine the cause of the disease and then carry out symptomatic treatment.