Multiple patchy abnormal signaling shadows in the subcortical areas of the frontal lobes bilaterally are considered for multiple sclerosis, subcortical arteriosclerotic encephalopathy, and other diseases. 1. Multiple sclerosis: The disease develops with weakness of one or more limbs, which may manifest as hemiplegia, paraplegia, quadriplegia, etc. It may be accompanied by sensory abnormalities and vision loss. Multiple patchy abnormal signal shadows in the subcortical area of bilateral frontal lobe can be seen in head CT or MRI examination. 2. Subcortical arteriosclerotic encephalopathy: there may be no obvious symptoms in the early stage of the disease, and some patients may suffer from memory loss. Head CT or MRI examination may show multiple patchy abnormal signal shadows in the subcortical area of bilateral frontal lobe. 3. Other diseases: such as cerebral white matter lesions caused by various reasons, traumatic brain injury, chronic ischemia of the brain, etc., all of which can show abnormal signals in the bilateral frontal subcortical area. Multiple patchy abnormal signals in the bilateral frontal subcortical area suggest that there is a lesion in this area, but the specific causes need to be combined with the medical history, physical examination and other relevant tests to assist in the diagnosis. After the discovery of multiple patchy abnormal signals in the bilateral frontal subcortical area, it is recommended to consult a doctor in a timely manner, complete the auxiliary examinations under the guidance of the doctor, and treat the cause of the disease after clarification.