The most common cause of pain and itchiness in the lips is local skin allergic reaction, while diseases such as herpes simplex and labyrinthitis around the mouth and lips can also lead to pain and itchiness for the following reasons: 1. Allergic reaction: cosmetic products used externally to stimulate the skin, such as lipstick and lipstick, lead to local allergic reaction, which may result in skin erythema, itching, pain and other symptoms, and in severe cases, blisters may also appear; 2. Herpes: at the beginning of herpes, the local pain and itching symptoms will be more obvious, and soon there will be clusters of blisters; 3, lipitis: lipitis will lead to pain and itchy lips, but also easy to cause dry and cracked lips, chronic lipitis is more common, mostly caused by cold stimulation, in addition to patients often lick lips, bite lips also easily lead to the occurrence of lipitis. Therefore, when the lips appear painful and itchy feeling, you should promptly go to the hospital for examination and use medication under the guidance of the doctor, such as applying fluorescence easy ointment, gentamycin ointment. If there are cracks on the lips, you can apply petroleum jelly for moisturizing. If the affected area has obvious oozing and crusting, apply saline wet compress and then apply gentamycin ointment. For painful and itchy symptoms caused by herpes attacks, anti-viral medication is recommended.