HPV16 positive refers to the infection of human papillomavirus type 16, most people are transient infection can be self-cured, a small number of persistent infection is not very good cure, the treatment process is relatively long, the specific results vary from person to person. HPV16 positive is a high-risk type of HPV infection, patients usually have low immunity, the treatment process is longer, in order to avoid persistent infection leading to cervical lesions, it is recommended that patients early treatment. Patients mainly use recombinant human interferon α2b vaginal effervescent tablets, pau gynecol suppositories and other drugs. Patients need to do colposcopy, when warts appear can consider the use of freezing, electrocautery, laser and other physical therapy methods. It is recommended that patients should prohibit smoking and alcohol, need to pay attention to rest, balanced nutrition, ensure sufficient sleep, maintain a pleasant mental state, enhance immunity has a positive effect on the elimination of HPV16. If diagnosed as HPV16 positive, it is recommended that early standardized treatment to reduce the adverse effects of the disease.