The stomach pain and diarrhea after drinking wine may be caused by functional dyspepsia, acute gastroenteritis, duodenal ulcer and other diseases. 1. Functional dyspepsia: this disease is the result of a combination of high visceral sensitivity, excessive stomach acid, heredity, poor dietary habits, mental psychology and other factors, mainly manifested in abdominal pain, diarrhea and other symptoms. 2. Acute gastroenteritis: this disease may be caused by rotavirus, Escherichia coli and other pathogenic microbial infections, and may also be caused by eating irritating food, seafood allergy, alcoholism and other factors, so the patient will have stomach pain, diarrhea and other symptoms after drinking. 3. Duodenal ulcer: the basic causes of this disease include Helicobacter pylori infection, heredity, increased secretion of gastric acid and pepsin, etc. It can be triggered by long-term alcohol consumption, mental stress, irregular eating and other factors, which leads to stomach pain and diarrhea after drinking. It is recommended that patients with stomach pain and diarrhea after drinking alcohol should go to the hospital for consultation to clarify the specific causes.