A slightly lower F-PSA/T-PSA (i.e., free prostate-specific antigen/total prostate-specific antigen) test ratio, with a normal F-PSA as well as a normal T-PSA, is considered to be due to factors such as a recent prostate massage or the presence of prostatitis. 1. Recent prostate massage: Patients who have had a prostate massage before the PSA test may have inaccurate test results and a decreased F-PSA/T-PSA. It is often necessary to retest the PSA after a period of time. 2. Prostatitis: Patients with prostatitis will often have a decreased F-PSA/T-PSA due to mildly elevated T-PSA. Patients can be treated with antibiotics such as cefotaxime and ceftriaxone under the guidance of a physician. After regular treatment, the patient’s F-PSA/T-PSA can gradually return to normal levels. Under normal circumstances, serum total PSA (T-PSA) <4 μg/L, free PSA (F-PSA) <0.8 μg/L, and F-PSA/T-PSA >25%, F-PSA/T-PSA >25% suggests benign prostatic lesions, and F-PSA/T-PSA <25% suggests a high risk of prostate cancer. F-PSA/T-PSA alone cannot determine what kind of disease is causing the problem, and it is necessary to combine it with other clinical findings. It is recommended that patients with abnormal F-PSA/T-PSA results should seek medical attention to identify the cause.