Cardiovascular spasm can be oral calcium channel blockers such as nifedipine, verapamil, nitrates such as isosorbide mononitrate and other drugs. A common type of cardiovascular spasm is coronary artery spasm, also clinically known as variant angina pectoris, which is due to spasm of the coronary arteries, resulting in insufficient blood supply to the myocardium, leading to chest pain, chest tightness and other symptoms, and may also be complicated by arrhythmia. Currently, commonly used drugs include calcium channel blockers and nitrates, the former including nifedipine, verapamil, diltiazem, etc., which can relax smooth muscle, relieve vasospasm, and dilate coronary blood vessels. Nitrate esters include isosorbide mononitrate, isosorbide nitrate, etc., which can effectively dilate coronary blood vessels and relieve myocardial ischemia and hypoxia. The occurrence of cardiovascular spasm, it is recommended that timely medical treatment, the use of drugs need to be under the guidance of a professional doctor.