There is no such thing as the latest and most effective treatment for pyriformis syndrome. At present, the main conservative treatment, drug treatment and surgery are the main treatment. 1. Conservative treatment: early pyriformis syndrome can be treated conservatively, feasible massage, local manipulation massage, physiotherapy or pyriformis muscle closure, can effectively relieve the spasm of the pyriform muscle and adhesion. 2.Drug treatment (1) Intravenous mannitol and dexamethasone injection: the combined application of dehydration and anti-inflammatory drugs can effectively reduce the edema of the pyriformis muscle, and can make the pyriformis muscle in a state of relaxation, reduce the inflammation, and reduce the stimulation of the nerves and other tissues, and the symptom will be significantly relieved. (2) Non-steroidal anti-inflammatory and analgesic drugs: non-steroidal anti-inflammatory drugs such as Loxoprofen Sodium, Diclofenac Sodium, and so on, these drugs are able to effectively control the local inflammation, reduce inflammatory edema and pain. (3) Muscle relaxants: such as eperisone hydrochloride tablets, etc., after oral intake can make the tense pyriformis muscle in a state of relaxation, after relaxation can help its functional recovery and the elimination of inflammatory edema. 3. Surgery: If the non-surgical treatment is ineffective and the diagnosis is accurate, surgical exploration can be carried out to release the nerve compression according to the mutation of the muscle, whether there is scar adhesion, whether there is bone scab compression, nerve path mutation and other reasons. The outcome of surgery is highly dependent on the duration of the disease. If pyriformis syndrome is diagnosed, it is recommended to go to the orthopedic department of a regular hospital for standardized treatment.