Creatinine 110μmol/L is generally abnormal, which may be caused by physiological factors such as eating a large amount of meat or pathological factors such as high blood pressure, diabetes mellitus, and primary kidney disease. The normal range of creatinine is 53~106μmol/L for adult male and 44~97μmol/L for adult female, but the testing standard may be different in each hospital. 110μmol/L creatinine is generally abnormal and may be caused by the following reasons. 1. Physiological factors: such as eating a large amount of meat, strenuous exercise and so on can also appear creatinine elevation. 2. High blood pressure: If high blood pressure persists for a long time, it may damage the kidneys, and then creatinine elevation occurs. Generally speaking, drugs can be used for treatment, common drugs are nifedipine tablets, valsartan and so on. At the same time in life, but also to adjust the diet, reduce the intake of sodium. 3. Diabetes mellitus: If the history of diabetes mellitus is long, renal function damage can occur, thus creatinine increase, you can take metformin, nateglinide and other drugs to control blood glucose, reduce the burden on the kidneys, reduce the value of creatinine. 4. Primary renal disease: primary renal disease will lead to thickening of glomerular filtration membrane and decrease of filtration function, so that creatinine can not be metabolized quickly, and creatinine is elevated. If creatinine is persistently high for a long time, you should consult the doctor in time to clarify the cause of the disease and take targeted treatment according to the doctor’s instructions.